This four-session seminar introduces students to the ethical implications of public health programs, policies, and research initiatives; their historical roots; and the regulations and guidelines governing human subjects research in the United States and internationally. Case studies are used to demonstrate selected ethical challenges in public health policy, practice, and research. In addition, students learn the functions and procedures of Yale’s Human Research Protection Program and complete its Web-based training on human subjects research. M.P.H. students are required to take the course during the first year of the program.